Search on: COAGULATION FACTOR VIIIA 
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Descriptor English:   Factor VIIIa 
Descriptor Spanish:   Factor VIIIa 
Descriptor Portuguese:   Fator VIIIa 
Synonyms English:   Factor VIII, Activated
Factor VIII, Thrombin-Activated
Coagulation Factor VIIIa  
Tree Number:   D12.776.124.125.350.300
D23.119.350.300
Definition English:   Activated form of factor VIII. The B-domain of factor VIII is proteolytically cleaved by thrombin to form factor VIIIa. Factor VIIIa exists as a non-covalent dimer in a metal-linked (probably calcium) complex and functions as a cofactor in the enzymatic activation of factor X by factor IXa. Factor VIIIa is similar in structure and generation to factor Va. 
Entry Combination - descr/qualif English:   Factor VIIIa/deficiency use Hemophilia A
 
See Related English:   Coagulants
 
History Note English:   90 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   24644 
Unique Identifier:   D015944 

Occurrence in VHL: 		 

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